TABLE 4.

Genome‐wide significant (p < 5 × 10⁻⁸) variants associated with all‐cause dementia in cross‐ancestry meta‐analysis.

rsID	Nearest gene	Chr	Pos	EA/NEA	P value	MAF	Beta	SE
rs10402524	BCAM	19p11	45329344	T/C	1.21E‐17	0.2336	−0.168	0.045
rs744373	BIN1	2q14.3	127894615	A/G	1.90E‐17	0.358	−0.139	0.031
rs2278867	MS4A6A	11q13.1	59943109	A/T	1.72E‐15	0.2897	0.113	0.020
rs10792832	PICALM	11q13.1	85867875	A/G	3.77E‐12	0.3135	−0.074	0.036
rs10948367	CD2AP	6q14.3	47585615	A/G	1.67E‐11	0.2328	−0.042	0.017
rs1408077	CR1	1q11.1	207804141	A/C	4.75E‐10	0.1412	0.088	0.055
rs4295	ACE	17q21.1	61556298	C/G	1.60E‐09	0.3666	−0.066	0.018
rs2208524	CHD6	20q11.21	40423299	T/C	1.66E‐09	0.1268	−0.103	0.027
rs11691153	DAW1	2q14.1	228780072	T/C	1.83E‐09	0.1536	0.099	0.025
rs6853262	LPHN3	4q22.1	61221892	C/T	6.22E‐09	0.06989	0.208	0.112
rs2677386	PWRN2	15q15.1	24432053	T/C	7.18E‐09	0.3612	−0.083	0.017
rs7006786	ARHGEF10	8q13.2	1792639	G/A	8.81E‐09	0.08986	0.097	0.045
rs35483531	DEGS2	14q21.3	100653772	C/T	1.35E‐08	0.2993	−0.004	0.024
rs170084	PMFBP1	16q11.2	72178483	T/A	2.79E‐08	0.107	−0.068	0.029
rs10940421	SNX18	5q14.3	54036059	A/G	3.34E‐08	0.372	0.040	0.017
rs138908633	EPB41L4A	5q14.3	111649017	G/A	3.76E‐08	0.03095	−0.029	0.050
rs74435987	DUSP6	12q14.1	89152253	G/T	4.20E‐08	0.08766	0.078	0.130
rs11225924	DDI1	11q13.1	103493165	C/T	4.27E‐08	0.1034	0.152	0.105
rs113747850	MAPK9	5q14.3	179710663	T/C	4.93E‐08	0.123	0.071	0.024

Note: The meta‐analysis includes European, African, Asian, and Hispanic/Latino ancestries. Three new variants at 20q11.21, 2q14.1, and 15q15.1 reached genome‐wide significance (highlighted in orange).

Abbreviation: MAF, minor allele frequency.