TABLE 4.
Association of viral genotype with levels of reduced susceptibility to lopinavir
Mutation | No. of occurrences |
Pa for cutoff of fold lopinavir IC50
|
|||
---|---|---|---|---|---|
4 | 10 | 20 | 40 | ||
L10F/I/R/V | 45 | 0.0013 | 0.0013 | 0.0261 | ns |
K20M/R | 13 | ns | ns | 0.0028 | ns |
L24I | 8 | ns | ns | ns | ns |
M46I/L | 27 | ns | ns | ns | ns |
F53L | 9 | ns | ns | 0.0479 | 0.0173 |
I54L/T/V | 27 | <0.0001 | <0.0001 | <0.0001 | 0.0016 |
L63P | 49 | 0.0371 | 0.0160 | ns | ns |
A71I/L/V/T | 35 | 0.0137 | 0.0301 | ns | ns |
V82A/F/T | 26 | <0.0001 | <0.0001 | 0.0005 | 0.0011 |
I84V | 14 | 0.0121 | ns | ns | ns |
L90M | 32 | ns | ns | ns | ns |
P values <0.0075 were considered statistically significant; P values between 0.05 and 0.0075 were considered marginally significant; P values >0.05 were considered not significant (ns).