Fig. 1.

Associations between CRAR parameters and incident dementia. Restricted cubic spline models fitted for Cox proportional hazards models with three knots. Dashed vertical red lines represent the turning point for the association between M10 and the incidence of dementia. The HRs were adjusted for age, sex, education levels, ethnicity, the Townsend index of deprivation, recruitment center, season of accelerometer wear, smoking status, alcohol intake, healthy diet score, obesity, history of diabetes, hypertension, depression and APOE ε4 status. APOE, apolipoprotein E; CI, confidence interval; CRAR, circadian rest‐activity rhythm; HR, hazard ratio; L5, the least active 5‐h period; M10, the most active 10‐h period; RA, relative amplitude; IS, interdaily stability; IV, intradaily variability; a.u., arbitrary unit.