Table 4.
Genes altered by AUD status
| Current Study |
Bailey et al. (75) |
|||||
|---|---|---|---|---|---|---|
| Gene Name | Log 2 Fold Change | P Value | Adj. P Value | Log 2 Fold Change | P Value | Adj. P Value |
| CEACAM7 | 4.82 | 0 | 0 | 2.58 | 0.014 | 0.180 |
| S100A8 | 4.78 | 0 | 0 | 2.10 | 0.021 | 0.210 |
| CYSRT1 | 3.43 | 0 | 0 | 1.06 | 0.018 | 0.195 |
| CEACAM5 | 3.39 | 0 | 0.01 | 4.18 | 0.001 | 0.055 |
| PADI1 | 3.33 | 0 | 0 | 1.55 | 0.015 | 0.186 |
| ABCA12 | 2.09 | 0 | 0.02 | 2.34 | 0.010 | 0.160 |
| CRYBG2 | 1.62 | 0 | 0.01 | 1.32 | 0.017 | 0.192 |
| PLBD1 | 1.41 | 0 | 0.05 | 0.77 | 0.008 | 0.142 |
| BDKRB2 | 1.24 | 0 | 0 | 0.42 | 0.052 | 0.309 |
| GPRC5B | −1.63 | 0 | 0.02 | −0.84 | 0.023 | 0.223 |
| MUC5B | −2.93 | 0 | 0.01 | −2.05 | 0.004 | 0.102 |
| CYP2A13 | −3.99 | 0 | 0.05 | −2.09 | 0.002 | 0.085 |
| ITLN1 | −4.57 | 0 | 0 | −3.18 | 0.011 | 0.161 |
Examples of genes comparably differentially regulated in our comparison of cultured alcohol use disorder (AUD) and non-AUD cells and data from Bailey et al. (75), which were processed for AUD status, but not smoking status. Although both sets of data had significant P values, the adjusted P value for these genes was not significant for the Bailey et al. data, which is a limitation of this analysis.