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. 2024 Oct 10;12:1491740. doi: 10.3389/fcell.2024.1491740

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Copyright © 2024 Zhao, Luo, Zhang, Fan, Zhang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Kaempferol inhibits the hyperproliferation of ISCs in aging via the insulin signaling pathway. (A) p-AKT staining (red) in aged esg-GFP⁺ cells of Drosophila midguts, visualized through immunofluorescence imaging, comparing samples with and without Kaempferol treatment. The top images show merged images and the bottom images display p-AKT signals. (B) Quantitation of p-AKT fluorescence intensity in esg-GFP⁺ cells. Each dot indicates one esg-GFP⁺ cell. (C) Immunofluorescence images of ISCs in UAS-LacZ, UAS-InRDN, and InR RNAi Drosophila midguts, with or without Kaempferol treatment (starting from day 26). The top images show merged images, while the bottom images display esg⁺ cells. (D) The proportion of esg-GFP⁺ cells to DAPI⁺ cells per ROI in experiment (C). (E) The number of pH3⁺ cells per fly gut.