Table 2.
Clinical functional and inflammatory characteristics.
| Variables | AnH = 181 | AwH = 79 | p-value | |
|---|---|---|---|---|
| FEV1, L | 2.52 (1.94–3.12) | 2.08 (1.73–2.69) | <0.001 | |
| FEV1, % predicted | 91.5 (79.0–105.0) | 87.0 (68.0–106.0) | 0.351 | |
| FVC, L | 3.59 (1.11) | 3.08 (0.97) | 0.001 | |
| FVC, % predicted | 101.5 (91–116.0) | 94 (82–115.0) | 0.036 | |
| FEV1/FVC, % | 73.0 (65.4–79.8) | 72.7 (66.0–79.0) | 0.929 | |
| FEV1 post BD, L | 2.72 (2.17–3.23) | 2.17 (1.74–2.70) | <0.001 | |
| FVC post BD, L | 3.50 (2.91–4.19) | 2.93 (2.41–3.73) | <0.001 | |
| FEV1/FVC post BD, % | 76.00 (68.00–82.03) | 74.00 (68.00–82.00) | 0.606 | |
| Blood Leucocytes, | 6.69 (5.72–7.86) | 6.98 (5.81–8.42) | 0.149 | |
| Blood Neutrophils, % | 53.40 (8.57) | 54.20 (8.22) | 0.529 | |
| Blood Lymphocytes, % | 31.90 (27.30–37.65) | 29.50 (25.68–35.90) | 0.084 | |
| Blood Eosinophils, % | 4.00 (2.05–7.20) | 3.95 (1.98–6.60) | 0.795 | |
| Blood Eosinophils, ucl | 262.40 (139.10–533.04) | 269.62 (130.24–473.72) | 0.804 | |
| Blood Neutrophils, ucl | 3542.40 (2862.0–4261.78) | 3730.10 (3232.10–4618.90) | 0.078 | |
| Blood Lymphocytes, ucl | 2097.03 (1793.45–2490.68) | 2084.10 (1706.37–2601.27) | 0.789 | |
| NLR, median (IQR) | 1.67 (1.27–2.16) | 1.84 (1.40–2.27) | 0.112 | |
| Total IgE, U/L | 199.00 (91.90–578.00) | 177.0 (45.30–437.00) | 0.696 | |
| Cells x104/ml IS, | 148.50 (64.00–267.00) | 140.00 (75.00–285.00) | 0.856 | |
| IS Macrophages %, median (IQR) | 17.70 (7.93–29.70) | 15.80 (6.30–26.10) | 0.203 | |
| IS Neutrophils %, median (IQR) | 51.15 (20.60–74.18) | 63.40 (21.90–78.70) | 0.072 | |
| IS Eosinophils %, median (IQR) | 6.60 (0.95–33.97) | 5.60 (1.90–24.30) | 0.656 | |
| IS Lymphocytes %, median (IQR) | 1.00 (0.40–2.00) | 1.20 (0.40–1.90) | 0.681 | |
| IS Epithelial %, median (IQR) | 3.30 (1.60–7.85) | 3.70 (1.60–6.30) | 0.718 | |
| IS Viability %, median (IQR) | 82.30 (66.58–90.43) | 82.00 (68.00–90.00) | 0.881 | |
| IS Neutrophils ≥61%, n (%) | 71 (39.2) | 44 (55.7) | 0.014 | |
| Inflammatory patterns n (%) | Neutrophilic | 48 (26.5) | 21 (26.6) | 0.007* |
| Eosinophilic | 86 (47.5) | 24 (30.4) | ||
| Mixed granulocytic | 23 (12.7) | 23 (29.1) | ||
| Paucigranulocytic | 24 (13.3) | 11 (13.9) | ||
Data are presented as number (n) and percentage (%) for dichotomous values or mean (± standard deviation) for quantitative variables or median (IQR) for skewed variables. AnH, asthma no hypertension; AwH, asthma with hypertension; FEV1, forced expiratory volume in the first second; IQR, inter-quartile range; FVC, forced vital capacity; BD, bronchodilator test; NLR, blood neutrophil-to-lymphocyte ratio IS, induced sputum.; *Eosinophilic pattern, p = 0.01; Mixed granulocytic pattern, p = 0.014. Bold p-value <0.05.