Extended Data Fig. 6. Line attractor dynamics across the estrus cycle.

a, Correlation between female estrus states and the presence of sexual receptivity, measured by whether female displayed accepting behaviors during interaction with male. b, Photometry recording in female VMHvl α cells during receptive and unreceptive mating interactions. Data presented as mean ± SEM. c, Low dimensional principal components of VMHvl α dynamical system in receptive day with neural data projected from unreceptive day. d, Flow field of VMHvl α dynamical system in receptive day with neural trajectories projected from unreceptive for t = 0 to t = 200 s (left) and t = 200 s to t = 400 s (right). e, Quantification of normalized value of integration dimension during male-mounting in unreceptive and receptive days (*p < 0.05, N = 4 mice, mean value during unreceptive day: 0.09 ± 0.04, receptive day: 0.69 ± 0.05. Mann-Whitney U test, p value: 0.02). f, Dynamics of integration dimension in two more example mice discovered during receptive day compared to activity of the same dimension on unreceptive days.