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. 2023 Oct 27;14(12):3322–3338. doi: 10.1007/s13346-023-01456-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Cytotoxicity of DOXC₁₂ and DOXC₁₂-LNC^CL in GL261 cells for 72 h. The cytotoxic effect of the treatments was assessed by crystal violet assay and presented in curve graph (A) and bar graph (B). The percentage of cell survival is compared to untreated cells (assumed as 100%) (mean ± SD, n = 3). Statistical analyses were performed using unpaired t-test for the IC₅₀ values (A) and two-way ANOVA with Bonferroni’s multiple comparisons test for bar graph (B) (**p < 0.01, ****p < 0.0001)