Table 2.
Association between baseline risk factors and fracture: compare the regression coefficients between the conventional Cox’s proportional hazard model with no competing risk adjustment, and the competing risk models, including the cause-specific model, the Fine-Gray model, and the multistate model
| Model with no competing risk adjustment | Model with competing risk adjustment | ||||
|---|---|---|---|---|---|
| Conventional Cox’s proportional hazard model | Cause-specific model | Fine-Gray model | Multistate model | ||
| Outcome of interest | Fracture | Fracture | Death | Fracture | Fracture |
| Predictors | |||||
| Sex (women) |
1.44 (1.19, 1.74) |
1.44 (1.19, 1.74) |
0.58 (0.49, 0.68) |
1.72 (1.45, 2.04) |
1.44 (1.19, 1.74) |
| Age (+ 1 year) |
1.03 (1.02, 1.05) |
1.03 (1.02, 1.05) |
1.13 (1.11, 1.14) |
0.99 (0.98, 1.01) |
1.03 (1.02, 1.05) |
| Femoral neck bone mineral density T-score (− 1) |
1.50 (1.38, 1.63) |
1.50 (1.38, 1.63) |
0.99 (0.91, 1.07) |
1.41 (1.32, 1.51) |
1.50 (1.38, 1.63) |
| History of falls in the last 12 months |
1.07 (0.94, 1.22) |
1.07 (0.94, 1.23) |
0.77 (0.66, 0.91) |
1.20 (1.07, 1.35) |
1.07 (0.94, 1.23) |
| Prior fracture after the age of 50 years prior to recruitment |
1.92 (1.56, 2.37) |
1.92 (1.56, 2.37) |
1.25 (0.95, 1.63) |
1.62 (1.35, 1.95) |
1.92 (1.56, 2.37) |
| Discriminative performance | |||||
| C-statistic (95% CI) |
0.70 (0.68, 0.72) |
0.70 (0.68, 0.72) |
0.73 (0.71, 0.75) |
0.68 (0.66, 0.70) |
0.71 (0.70, 0.73) |
Data presented as hazard ratios (95% CI), unless otherwise indicated