Table 2.
Screening analysis of antioxidant-related gene expression in peripheral blood mononuclear cells (PBMCs) of 24 drinkers.
| Gene | Drinkers | Gene | Drinkers | ||||
|---|---|---|---|---|---|---|---|
| Light (n = 8) | Moderate (n = 8) | Heavy (n = 8) | Light (n = 8) | Moderate (n = 8) | Heavy (n = 8) | ||
| ALB | ND | ND | ND | MTL5 | ND | ND | ND |
| ALOX12 | 1.13 ± 0.50 | 0.85 ± 0.47 | 0.99 ± 0.36 | NCF1 | 1.64 ± 0.42 | 1.14 ± 0.49 | 1.08 ± 0.49 |
| ANGPTL7 | ND | ND | ND | NCF2 | 1.38 ± 0.59 | 1.40 ± 0.59 | 1.59 ± 0.61 |
| AOX1 | ND | ND | ND | NME5 | ND | ND | ND |
| APOE | ND | ND | ND | NOS2 | ND | ND | ND |
| ATOX1 | 5.56 ± 2.37 | 5.94 ± 2.39 | 6.42 ± 2.35 | NOX5 | ND | ND | ND |
| BNIP3 | 1.31 ± 0.23 | 0.51 ± 0.23 | 0.38 ± 0.17 | NUDT1 | 0.38 ± 0.15 | 0.27 ± 0.12 | 0.35 ± 0.15 |
| CAT | 1.52 ± 0.46 | 0.90 ± 0.27 | 1.75 ± 0.47 | OXR1 | 0.48 ± 0.15 | 0.33 ± 0.16 | 0.43 ± 0.18 |
| CCL5 | 1.27 ± 0.49 | 0.97 ± 0.32 | 0.59 ± 0.23 | OXSR1 | 0.58 ± 0.16 | 0.59 ± 0.25 | 0.72 ± 0.29 |
| CCS | 0.44 ± 0.14 | 0.39 ± 0.11 | 0.52 ± 0.15 | PDLIM1 | 1.56 ± 0.59 | 0.71 ± 0.23 | 0.74 ± 0.23 |
| CSDE1 | 2.92 ± 1.19 | 1.72 ± 0.62 | 2.86 ± 1.32 | PIP3-E | 0.54 ± 0.15 | 0.51 ± 0.25 | 0.48 ± 0.18 |
| CYBA | 2.16 ± 0.91 | 0.73 ± 0.27 | 1.05 ± 0.27 | PNKP | 0.42 ± 0.14 | 0.29 ± 0.12 | 0.36 ± 0.14 |
| CYGB | ND | ND | ND | PRDX1 | 0.31 ± 0.12 | 0.25 ± 0.12 | 0.35 ± 0.14 |
| DGKK | 1.38 ± 0.44 | 0.71 ± 0.25 | 1.04 ± 0.35 | PRDX2 | 0.61 ± 0.22 | 0.61 ± 0.25 | 0.61 ± 0.32 |
| DHCR24 | 0.40 ± 0.14 | 0.43 ± 0.17 | 0.40 ± 0.14 | PRDX3 | 0.30 ± 0.11 | 0.21 ± 0.11 | 0.22 ± 0.03 |
| DUOX1 | ND | ND | ND | PRDX4 | 0.48 ± 0.14 | 0.43 ± 0.21 | 0.50 ± 0.22 |
| DUOX2 | ND | ND | ND | PRDX5 | 0.50 ± 0.16 | 0.50 ± 0.25 | 0.42 ± 0.14 |
| DUSP1 | 1.40 ± 0.62 | 1.92 ± 0.96 | 1.75 ± 0.90 | PRDX6 | 1.13 ± 0.46 | 0.66 ± 0.24 | 0.65 ± 0.20 |
| EPHX2 | 1.40 ± 0.44 | 0.55 ± 0.17 | 0.75 ± 0.29 | PREX1 | 0.32 ± 0.12 | 0.25 ± 0.12 | 0.27 ± 0.08 |
| EPX | ND | ND | ND | PRG3 | ND | ND | ND |
| FOXM1 | 0.54 ± 0.15 | 0.37 ± 0.15 | 0.52 ± 0.17 | PRNP | 0.69 ± 0.15 | 0.54 ± 0.18 | 0.44 ± 0.18 |
| GLRX2 | ND | ND | ND | PTGS1 | 0.46 ± 0.17 | 0.33 ± 0.24 | 0.36 ± 0.15 |
| GPR156 | ND | ND | ND | PTGS2 | 0.49 ± 0.16 | 0.48 ± 0.24 | 0.36 ± 0.14 |
| GPX1 | 0.98 ± 0.31 | 1.74 ± 0.45 | 0.70 ± 0.14 | PXDN | ND | ND | ND |
| GPX2 | ND | ND | ND | PXDNL | ND | ND | ND |
| GPX3 | 0.59 ± 0.16 | 0.43 ± 0.17 | 0.42 ± 0.17 | RNF7 | 0.51 ± 0.14 | 0.39 ± 0.14 | 0.36 ± 0.15 |
| GPX4 | 0.50 ± 0.16 | 0.37 ± 0.15 | 0.40 ± 0.15 | SCARA3 | ND | ND | ND |
| GPX5 | ND | ND | ND | SELS | 4.51 ± 1.88 | 5.63 ± 2.24 | 4.15 ± 1.34 |
| GPX6 | ND | ND | ND | SEPP1 | 0.59 ± 0.15 | 0.42 ± 0.24 | 0.43 ± 0.18 |
| GPX7 | 1.29 ± 0.43 | 0.62 ± 0.22 | 1.14 ± 0.43 | SFTPD | 0.49 ± 0.16 | 0.42 ± 0.24 | 0.37 ± 0.15 |
| GSR | 0.86 ± 0.28 | 0.81 ± 0.47 | 0.76 ± 0.28 | SGK2 | 7.24 ± 2.7 | 7.38 ± 0.32 | 6.38 ± 2.62 |
| GSS | 0.32 ± 0.12 | 0.31 ± 0.12 | 0.36 ± 0.15 | SIRT2 | 0.31 ± 0.12 | 0.29 ± 0.13 | 0.35 ± 0.14 |
| GSTZ1 | 0.49 ± 0.17 | 0.52 ± 0.25 | 0.46 ± 0.14 | SOD1 | 1.20 ± 0.23 | 0.62 ± 0.20 | 0.54 ± 0.13 |
| GTF2I | 0.33 ± 0.12 | 0.28 ± 0.09 | 0.26 ± 0.07 | SOD2 | 0.48 ± 0.16 | 0.42 ± 0.24 | 0.48 ± 0.18 |
| KRT1 | ND | ND | ND | SOD3 | ND | ND | ND |
| LPO | ND | ND | ND | SRXN1 | 0.28 ± 0.12 | 0.28 ± 0.13 | 0.36 ± 0.15 |
| MBL2 | ND | ND | ND | STK25 | 0.61 ± 0.15 | 0.51 ± 0.24 | 0.54 ± 0.16 |
| MGST3 | 1.99 ± 0.99 | 1.73 ± 0.68 | 2.11 ± 1.23 | TPO | ND | ND | ND |
| MPO | 0.31 ± 0.12 | 0.24 ± 0.12 | 0.27 ± 0.08 | TTN | 1.89 ± 0.35 | 0.86 ± 0.25 | 1.31 ± 0.61 |
| MPV17 | 0.85 ± 0.29 | 0.58 ± 0.25 | 0.71 ± 0.29 | TXNDC2 | ND | ND | ND |
| MSRA | 0.63 ± 0.24 | 0.54 ± 0.24 | 0.62 ± 0.18 | TXNRD1 | 0.41 ± 0.15 | 0.42 ± 0.24 | 0.36 ± 0.14 |
| MT3 | 1.51 ± 0.47 | 0.95 ± 0.34 | 0.94 ± 0.32 | TXNRD2 | 0.32 ± 0.12 | 0.41 ± 0.23 | 0.36 ± 0.15 |
Values are presented as means ± SEM. ND not determined.
Bold text indicates upregulated genes; that is, those with > 1.5-fold higher expression levels between any two of the three groups of drinkers.