Figure 2. Diabetic ketoacidosis occurrence rates by prespecified strata of maximum daily ambient temperature, in degrees Celsius, among sitagliptin (DPP-4i) and among exenatide (GLP1RA) users enrolled in five US state Medicaid programmes. Occurrence rates (ie, outcomes among exposed person-days) for dipeptidyl peptidase-4 inhibitors are represented by squares. Occurrence rates for glucagon-like peptide 1 receptor agonists are represented by triangles. We scaled the size of each data point to reflect its weight using the inverse of the variance estimate. Black-to-grey tones distinguish the antidiabetes agents. Black squares=sitagliptin. Dark grey triangles=exenatide. Corresponding confidence bands are dark grey and medium grey, respectively. P values for quadratic terms for maximum daily ambient temperature were 0.803 and 0.294 for sitagliptin and exenatide, respectively. P values for linear terms for maximum daily ambient temperature were 0.016 and 0.080 for sitagliptin and exenatide, respectively. P-y, person-years.