Table 2.
Cox regression analysis for atrial fibrillation/tachycardia recurrence within 1 year after AMD prescription
| Variables | Univariable | Model 1 (N = 115) | Model 2 (N = 115) | Model 3 (N = 115) | ||||
|---|---|---|---|---|---|---|---|---|
| HR, 95% (CI) | P value | HR, 95% (CI) | P value | HR, 95% (CI) | P value | HR, 95% (CI) | P value | |
| Age, per SD increase | 0.83 (0.63–1.10) | 0.200 | 0.80 (0.58–1.11) | 0.183 | 0.83 (0.60–1.15) | 0.258 | 0.84 (0.61–1.17) | 0.312 |
| Female | 1.06 (0.56–2.01) | 0.868 | 1.04 (0.49–2.20) | 0.922 | 1.00 (0.72–1.40) | 0.986 | 1.02 (0.73–1.42) | 0.919 |
| Paroxysmal AF | 1.08 (0.57–2.06) | 0.804 | 0.79 (0.37–1.71) | 0.553 | 0.87 (0.62–1.24) | 0.443 | 0.91 (0.64–1.3) | 0.618 |
| BMI, per SD increase | 1.13 (0.84–1.53) | 0.421 | 1.12 (0.81–1.55) | 0.497 | 1.01 (0.73–1.38) | 0.974 | 1.06 (0.77–1.46) | 0.719 |
| Repeat ablation | 1.84 (1.01–3.36) | 0.046 | 2.02 (0.97–4.19) | 0.060 | 1.45 (1.06–1.99) | 0.020 | 1.45 (1.06–1.97) | 0.020 |
| Congestive heart failure | 1.49 (0.84–2.66) | 0.176 | 2.75 (1.32–5.74) | 0.007 | 1.49 (1.04–2.15) | 0.032 | 1.49 (1.04–2.14) | 0.029 |
| Hypertension | 0.91 (0.51–1.63) | 0.751 | 1.60 (0.77–3.33) | 0.206 | 1.31 (0.91–1.88) | 0.152 | 1.26 (0.88–1.8) | 0.210 |
| Diabetes mellitus | 0.39 (0.14–1.08) | 0.069 | 0.32 (0.11–0.96) | 0.042 | 0.64 (0.42–0.99) | 0.043 | 0.65 (0.42–0.99) | 0.044 |
| LA dimension, per SD increase | 1.02 (0.77–1.36) | 0.888 | 0.91 (0.62–1.35) | 0.651 | 0.95 (0.64–1.40) | 0.787 | 0.95 (0.65–1.4) | 0.806 |
| LVEF, per SD increase | 1.22 (0.89–1.68) | 0.215 | 1.59 (1.11–2.28) | 0.012 | 1.56 (1.09–2.23) | 0.016 | 1.51 (1.06–2.17) | 0.024 |
| Use of virtually effective AMD | 0.37 (0.15–0.95) | 0.038 | 0.37 (0.14–0.98) | 0.046 | ||||
| Mean Smax in no AMD, per SD increase | 1.39 (1.05–1.84) | 0.023 | 1.21 (0.87–1.70) | 0.257 | ||||
| Mean Smax in low AMD, per SD increase | 1.32 (0.98–1.79) | 0.072 | ||||||
| Mean Smax in high AMD, per SD increase | 1.12 (0.83–1.51) | 0.457 | ||||||
| Highest Mean Smax in no AMD, per SD increase | 1.27 (0.94–1.71) | 0.114 | ||||||
| Highest Mean Smax in Low AMD, per SD increase | 1.05 (0.80–1.38) | 0.707 | ||||||
| Highest Mean Smax in High AMD, per SD increase | 0.92 (0.68–1.24) | 0.579 | ||||||
| Lowest Mean Smax in no AMD, per SD increase | 1.36 (1.07–1.73) | 0.011 | 1.26 (0.96–1.64) | 0.091 | ||||
| Lowest Mean Smax in Low AMD, per SD increase | 1.27 (0.97–1.68) | 0.086 | ||||||
| Lowest Mean Smax in High AMD, per SD increase | 1.19 (0.91–1.56) | 0.212 | ||||||
AF atrial fibrillation, AMD amiodarone, BMI body mass index, CI confidence interval, LA left atrial, LVEF left ventricular ejection fraction, SD standard deviation.