TABLE 4.

Phenotypes of hinge and RGD mutant viruses in vivo

Virus	Mutation	NV parametersa				NI parametersb
		HD50	% Mortality	Days (mean ± SD) to death	NVc	HD50	% Mortality	Days (mean ± SD) to death	NId
CDV-1-51	None	1	100	4.6 ± 0.5	H	5.0	100	7.2 ± 0.9	H
CDV-1-51v1	E-277 (S→I)	4	100	5.5 ± 0.5	H	>104.5	0	NAe	L
CDV-1-51v2	E-277 (S→N)	3	100	4.4 ± 0.5	H	4	90	7.3 ± 1.3	H
CDV-1-51v3	E-277 (S→V)	2	100	4.8 ± 0.8	H	620	40	8.5 ± 1.3	I
CDV-1-51v4	E-277 (S→P)	5	100	4.9 ± 0.3	H	580	50	10.2 ± 3.6	I
CDV-1-51v5	E-390 (D→N)	18	100	4.9 ± 0.6	H	>104.5	0	NA	L
CDV-1-51v6	E-390 (D→E)	1	100	4.3 ± 0.5	H	2	100	6.7 ± 0.8	H
CDV-1-51v7	E-390 (D→Y)	10	100	5.5 ± 0.5	H	>104.5	0	NA	L

^aNV was determined by i.c. inoculation of virus. 

^bNI was determined by i.p. inoculation of virus. 

^cNV was determined according to the criteria described by McMinn et al. (46). H, high (<20 PFU) level of virus. 

^dNI was determined according to the criteria described by McMinn et al. (46). H, high (< PFU); I, intermediate (<10³ PFU); L, low (>10³ PFU). 

^eNA, not applicable.