FIG. 7.
Effect of CAR expression on adenovirus-mediated CFTR expression by CF airway epithelia. Two days after CAR gene transfer, CF airway epithelia were infected with Ad2/CFTR-16 (MOI, 10) for 30 min from the apical surface. Forty-eight hours later the epithelia were studied in Ussing chambers. Data are changes in current (means + standard errors of the means [error bars]) after the addition of bumetanide to cyclic AMP-stimulated, amiloride-treated epithelia (ΔIBum) (n = 6). ∗, P < 0.01 compared to control.