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. Author manuscript; available in PMC: 2024 Oct 24.
Published in final edited form as: J Fluor Chem. 2023 Feb 21;267:110106. doi: 10.1016/j.jfluchem.2023.110106

Fig. 2.

Fig. 2.

Synthesis of novel 3rd-generation fluorotaxoids bearing 3-OCF3 or 3-OCF2H at the C2-benzoate moiety. (i) 3-CF3O or 3-CHF2O-benzoic acid, DIC, DMAP, CH2Cl2, r.t; ii) LiHMDS, THF, −40°C; iii) HF/pyridine, pyridine/MeCN, 0°C-r.t.