Skip to main content
. Author manuscript; available in PMC: 2024 Oct 24.
Published in final edited form as: J Fluor Chem. 2023 Feb 21;267:110106. doi: 10.1016/j.jfluchem.2023.110106

Fig. 5.

Fig. 5.

Synthesis of 3rd-generation DFV-taxoids bearing 3-OCF3 or 3-OCF2H at the C2-benzoate moiety. A: (i) O3, MeOH/CH2Cl2, −78°C, Me2S; ii) ClF2CCO2Na, Ph3P, DMF, 90°C; iii) CAN, MeCN/H2O, −10°C; iv) Boc2O, Et3N, DMAP, CH2Cl2, r.t; B: (i) LiHMDS, THF, −40°C; ii) HF/pyridine, pyridine/MeCN, 0°C-r.t.