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. Author manuscript; available in PMC: 2024 Oct 24.
Published in final edited form as: J Fluor Chem. 2023 Feb 21;267:110106. doi: 10.1016/j.jfluchem.2023.110106

Table 1.

Cytotoxicity (IC50 nM) of 3rd-generation fluorotaxoids.

Taxoid MCF-7 NCI/ADR LCC6-WT LCC6-MDR DLD-1 CFPAC-
PTX 0.9 130 1.81 619 364 60
SBT-1214 (1c) 0.74 0.88 0.91 3.19 3.4 0.71
1a-05 0.98 0.83 0.51 2.20 3.0 0.57
1b-05 0.37 0.43 0.71 2.40 3.1 0.75
1c-05 0.56 0.42 0.58 2.11 3.2 0.79
1d-05 0.28 0.66 0.74 2.15 3.3 0.69
1e-05 0.32 0.66 0.85 1.96 3.1 0.51
1a-06 0.34 0.45 0.42 2.01 2.9 0.48
1b-06 0.60 0.26 0.56 1.64 3.0 0.42
1c-06 0.37 0.36 0.45 1.80 3.1 0.39
1d-06 0.56 0.42 0.40 1.77 2.9 0.44
1e-06 0.41 0.39 0.67 1.75 3.0 0.49

MCF7: human breast cancer cell line.

NCI/ADR: drug-resistant (Pgp+) human ovarian cancer cell line.

LCC6-WT: human breast cancer cell line.

LCC6-MDR: drug-resistant (Pgp+) human breast cancer cell line.

DLD-1: drug-resistant (Pgp+) human colon cancer cell line.

CFPAC-1: human pancreatic cancer cell line.