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. Author manuscript; available in PMC: 2024 Oct 24.
Published in final edited form as: J Fluor Chem. 2023 Feb 21;267:110106. doi: 10.1016/j.jfluchem.2023.110106

Table 4.

Cytotoxicity (IC50 nM) of DFV-OTX in various drug-sensitive and drug-resistant breast cancer cells.

Cell lines PTX IC50 (nM) DFV-OTX IC50 (nM)
MCF-7R 17.37 8.15
MDA-MB-231R 550.80 138.50
MCF-7 2.94 3.11
MDA-MB-231 5.31 3.97
BT474 243.60 31.44
BT549 143.60 79.24
MDA-MB-453 3.39 3.07
293T 5.82 6.32
MCF-10A 3.40 2.68

MCF-7R: drug-resistant human breast cancer cell line.

MCF-7: human breast cancer cell line.

MCF-10A: non-malignant breast epithelial cells.

MDA-MB-231R: drug-resistant human breast cancer cell line.

MDA-MB-231: human breast cancer cell line.

MDA-MB-453: human metastatic breast cancer cell line.

BT474: human invasive breast cancer cell line.

BT549: human invasive and metastasized breast cancer cell line.

293T: human embryonic kidney cells.