Table 2.

Analysis of the association between metastases and genetic mutations.

genetic mutations	Metastasis			Lung metastasis			Brain metastasis			Bone metastasis			Live metastasis			Intrapulmonary metastasis			other siters metastasis
	Yes	No	P value	Yes	No	P value	Yes	No	P value	Yes	No	P value	Yes	No	P value	Yes	No	P value	Yes	No	P value
EGFR	431	447	0.584	166	712	0.004	166	712	0.001	238	640	0.004	47	831	0.553	168	710	0.313	47	831	0.015
ALK	44	18	<0.001	15	47	0.013	15	47	0.007	20	42	0.024	12	50	0.001	18	44	0.021	8	54	0.334
ROS1	10	6	0.237	5	11	0.045	3	13	0.42	2	14	0.747	0	16	0.613	6	10	0.044	2	14	0.649
RET	12	12	0.806	5	19	0.216	3	21	0.751	8	16	0.118	3	21	0.202	6	18	0.275	2	22	1.000
MET	14	8	0.139	2	20	1.000	5	17	0.168	7	15	0.175	0	22	0.63	4	18	0.774	3	19	0.445
KRAS	65	55	0.197	26	94	0.012	28	92	0.001	31	89	0.143	9	111	0.61	15	105	0.264	10	110	0.817
NRAS	5	0	0.025	3	2	0.017	0	5	1	2	3	0.259	0	5	1.000	3	2	0.038	0	5	1.000
BRAF	14	3	0.005	5	12	0.057	1	16	0.706	4	13	0.755	0	17	0.613	8	9	0.005	3	14	0.207
PIK3CA	1	3	0.625	0	4	1.000	0	4	1	0	4	0.324	0	4	1.000	1	3	0.523	0	4	1.000
HER2	13	33	0.014	2	44	0.107	6	40	0.773	8	38	0.721	4	42	0.522	4	42	0.158	2	44	0.406
Negative	184	204		48	340		45	343		76	312		24	364		65	323		35	353

P values in bold italic reached statistical significance.