Table 1.
Baseline demographic and medical characteristics of patients with skin cancer in the NHANES 1999–2018 cohort.
| Characteristics | ALI | |||||
|---|---|---|---|---|---|---|
| Total | Quantile 1 29.74 [4.14,37.87] |
Quantile 2 44.73 (37.87,52.84] |
Quantile 3 60.98 (52.84,73.20] |
Quantile 4 89.14 (73.20,977.87] |
P | |
| Participants, n | 1149 | 288 | 286 | 287 | 288 | |
| ALI, mean | 62.93 (58.87,67.00) |
29.39 (28.56, 30.21) |
45.11 (44.50, 45.72) |
61.61 (60.79, 62.44) |
105.64 (94.80,116.49) |
< 0.0001 |
| Age, year | 63.13 (62.14,64.13) |
68.04 (66.16,69.92) |
63.80 (61.81,65.79) |
61.89 (60.16,63.62) |
59.93 (58.20,61.66) |
< 0.0001 |
| Gender, n (%) | 0.57 | |||||
| Female | 496(43.17) | 104(44.26) | 126(48.56) | 120(43.48) | 146(49.43) | |
| Male | 653(56.83) | 184(55.74) | 160(51.44) | 167(56.52) | 142(50.57) | |
| Race, n (%) | 0.77 | |||||
| White | 1075(93.56) | 278(97.46) | 271(97.69) | 265(97.25) | 261(96.41) | |
| Black | 15(1.31) | 2(0.32) | 3(0.39) | 3(0.29) | 7(0.92) | |
| Mexican American |
25(2.18) | 2(0.17) | 7(0.59) | 8(0.76) | 8(0.42) | |
| Other | 34(2.96) | 6(2.05) | 5(1.33) | 11(1.69) | 12(2.25) | |
| BMI, Kg/m2 | 28.29 (27.87,28.71) |
25.64 (24.88,26.40) |
27.13 (26.43,27.84) |
28.78 (28.01,29.55) |
30.88 (30.05,31.72) |
< 0.0001 |
| Albumin, g/dL | 4.26 (4.24,4.28) |
4.18 (4.13,4.23) |
4.26 (4.22,4.30) |
4.30 (4.27,4.34) |
4.30 (4.26,4.33) |
< 0.001 |
| Neutrophil, K/uL | 4.24 (4.13,4.35) |
5.34 (5.03,5.65) |
4.49 (4.31,4.67) |
4.00 (3.84,4.15) |
3.40 (3.25,3.55) |
< 0.0001 |
| Lymphocyte, K/uL | 2.07 (1.86,2.29) |
1.44 (1.36,1.51) |
1.77 (1.71,1.83) |
1.99 (1.92,2.05) |
2.91 (2.20,3.61) |
< 0.0001 |
| ALT, U/L | 24.36 (23.19,25.53) |
22.01 (19.15,24.87) |
22.62 (21.10,24.15) |
26.55 (23.81,29.29) |
25.63 (24.07,27.19) |
0.03 |
| LDH, mmol/L | 136.94 (134.74,139.13) |
142.13 (137.54,146.73) |
135.30 (131.33,139.27) |
134.71 (131.77,137.66) |
136.44 (132.50,140.38) |
0.05 |
| Cr, umol/L | 83.44 (81.50,85.38) |
91.14 (84.48,97.80) |
81.81 (78.26,85.36) |
82.41 (80.15,84.67) |
79.88 (77.13,82.64) |
0.03 |
| Smoke status, n (%) | 0.86 | |||||
| Never | 508(44.21) | 132(48.93) | 116(43.49) | 123(46.10) | 137(47.59) | |
| Former | 508(44.21) | 126(36.65) | 133(43.55) | 128(40.53) | 121(40.99) | |
| Now | 133(11.58) | 30(14.42) | 37(12.96) | 36(13.37) | 30(11.42) | |
| Alcohol, n (%) | 0.11 | |||||
| Never | 129(11.23) | 43(11.96) | 25(7.26) | 29(7.55) | 32(9.68) | |
| Former | 264(22.98) | 76(20.61) | 68(19.82) | 63(16.95) | 57(14.72) | |
| Mild | 532(46.3) | 134(50.33) | 137(49.75) | 128(47.32) | 133(46.98) | |
| Moderate | 139(12.1) | 17(6.71) | 32(13.39) | 44(19.56) | 46(19.20) | |
| Heavy | 85(7.4) | 18(10.40) | 24(9.78) | 23(8.63) | 20(9.43) | |
| Hypertension, n (%) | 0.1 | |||||
| No | 435(37.86) | 83(34.61) | 118(47.10) | 113(41.35) | 121(45.45) | |
| Yes | 714(62.14) | 205(65.39) | 168(52.90) | 174(58.65) | 167(54.55) | |
| DM, n (%) | 0.1 | |||||
| No | 763(66.41) | 190(71.56) | 207(77.41) | 185(66.85) | 181(68.56) | |
| preDM | 119(10.36) | 34(9.28) | 19(6.01) | 29(9.23) | 37(12.93) | |
| DM | 267(23.24) | 64(19.16) | 60(16.58) | 73(23.91) | 70(18.51) | |
| CVD, n (%) | 0.1 | |||||
| No | 875(76.15) | 199(77.60) | 217(81.25) | 227(86.10) | 232(83.53) | |
| Yes | 274(23.85) | 89(22.40) | 69(18.75) | 60(13.90) | 56(16.47) | |
| Skin cancer, n (%) | 0.68 | |||||
| Melanoma | 234(20.37) | 49(18.03) | 64(24.15) | 61(19.80) | 60(19.83) | |
| Non-melanoma | 615(53.52) | 148(54.25) | 153(54.70) | 159(57.20) | 155(56.41) | |
| Skin (unknown) | 300(26.11) | 91(27.71) | 69(21.15) | 67(23.01) | 73(23.76) | |
ALI, advanced lung cancer inflammation index; BMI, body mass index; ALT, alanine aminotransferase; LDH, lactic dehydrogenase; Cr, creatinine; DM, diabetes mellitus; CVD, cardiovascular disease.
Values are weighted mean (IQR) for continuous variables or numbers (weighted %) for categorical variables. Wilcoxon rank-sum test was used for continuous variables, and chi-squared test with Rao & Scott’s second-order correction was used for categorical variables.