Table 1.
Comparison of the study groups regarding demographic and clinical characteristics.
| MDDm(n=20) | MDDu (n=20) | BD (n=21) | HC (n=23) | Group comparison (n=84) Test statistic |
Correction for ICV (n=84) P-value |
|
|---|---|---|---|---|---|---|
| Sex (male/female) | 8/12 | 7/13 | 9/12 | 9/14 | v23, N=84 = 0.27 | 0.97 |
| Age | 36.2 ± 12.8 | 42.9 ± 10.8 | 39.3 ± 12.0 | 36.0 ± 12.8 | F3, 80 = 1.47 | 0.23 |
| Intracranial volume (liter) | 1.54 ± 0.16 | 1.52 ± 0.15 | 1.53 ± 0.12 | 1.55 ± 0.12 | F3, 80 = 0.34 | 0.80 |
| Beck Depression Inventory II | 26.4 ± 10.2 | 21.6 ± 10.6 | 22.5 ± 13.4 | n.a. | F2, 58 = 0.97 | 0.38 |
| Bech–Rafaelsen Melancholia Scale | 16.3 ± 4.9 | 14.8 ± 7.9 | 18.6 ± 9.0 | n.a. | F2, 36 = 1.03w | 0.37 |
| Hamilton Rating Scale for Depression | 17.5 ± 6.9 | 16.2 ± 9.7 | 19.5 ± 8.9 | n.a. | F2, 58 = 0.78 | 0.46 |
| Inventory of Depressive Symptomology | 31.3 ± 12.4 | 30.9 ± 13.9 | 33.0 ± 15.9 | n.a. | F2, 58 = 0.13 | 0.88 |
| Years since 1st episode | 7.6 ± 10.4 | 13.3 ± 10.5 | 15.9 ± 10.6 | n.a. | F2, 57 = 3.20 | 0.048* |
*p ≤.05, AAN(C)OVA statistics, MDDm, Major Depressive disorder (medicated); MDDu, Major Depressive disorder (unmedicated); BD, Bipolar disorder; HC, healthy controls; ICV, Intracranial volume. The p values listed in the tables are not corrected for multiple testing using Bonferroni correction, n.a. not available, wWelch Statistic.