Table 1.
Summary of findings table.
| Summary of findings: | ||||||
|---|---|---|---|---|---|---|
| Clinical care with access to cerebral NIRS monitoring compared to clinical care without access to cerebral NIRS monitoring in children and adults | ||||||
| Patient or population: children and adults Setting: hospital Intervention: clinical care with access to cerebral NIRS monitoring Comparison: clinical care without access to cerebral NIRS monitoring | ||||||
| Outcomes | Anticipated absolute effectsa (95% CI) | Relative effect (95% CI) | No. of participants (studies) | Certainty of the evidence (GRADE) | Comments | |
| Risk with clinical care without access to cerebral NIRS monitoring | Risk with clinical care with access to cerebral NIRS monitoring | |||||
| All-cause mortality maximum follow-up (all-cause mortality) | 72 per 1000 |
54 per 1000 (37–79) |
RR 0.75 (0.51–1.10) |
1489 (11 RCTs) |
⨁◯◯◯ Very low |
Downgraded one level due to serious risk of bias and two levels for very serious imprecision due to the small information size (DARIS 14,509: Pc 7.2%; RR 20%; alpha 2.5%; beta 10%; diversity 0%) |
| Moderate or severe, persistent cognitive or neurological deficit, significantly affecting daily life at maximum follow-up (moderate or severe, persistent cognitive or neurologic deficit) | 138 per 1000 |
102 per 1000 (58–182) |
RR 0.74 (0.42–1.32) |
1135 (9 RCTs) |
⨁◯◯◯ Very low |
Downgraded one level due to serious risk of bias and two levels for very serious imprecision due to the small information size (DARIS 33,656: Pc 13.8%; RR 20%; alpha 2.5%; beta 10%; diversity 78.9%) |
| Proportion of participants with one or more serious adverse events (serious adverse events) | 424 per 1000 |
348 per 1000 (284–429) |
RR 0.82 (0.67–1.01) |
2132 (17 RCTs) |
⨁◯◯◯ Very low |
Downgraded one level due to serious risk of bias, one level for serious inconsistency due to significant heterogeneity despite excluding Mohandas et al. (2013) that had the largest effect size, and substantial variability in the effect estimates, and one level for serious imprecision due to the small information size (DARIS 7685: Pc 42.4%; RR 20%; alpha 2.5%; beta 10%; diversity 78.8%) |
GRADE Working Group grades of evidence: High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect.
CI confidence interval, RR risk ratio.
aThe risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).