Table 2.
Characteristics of patients with treatment for ocular inflammatory diseases and side effects
| Case | Sex | Age | OID | Active in OD/OS | Duration, month | Initial oral steroids (mg) | IMT, biologics | Side Effects | Associated systemic condition | Comments |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | F | 61 | SLE associated anterior uveitis | OS | 29 | No | - | - | HTN, hypothyroidism, Raynaud’s syndrome | RCI started with a dose of 40U three times/week. Disease was stable after 7 months and the dose kept as is for maintenance. |
| 2 | M | 18 | HLA-B27 + associated anterior uveitis | OD | 33 | 2.5 | - | Insomnia, anxiety | Obesity | RCI started with a dose of 80U three times/week. Disease was stable after 29 months and the dose was kept as is for maintenance. |
| 3 | M | 12 | Idiopathic posterior uveitis | OD | 16 | 4 | MMF | - | - | RCI was started with a dose of 40U three times/week. The disease was stable after 8 months and the dose kept as is for maintenance. |
| 4 | M | 40 | Idiopathic panuveitis | OD | 83 | No | - | - | - | RCI started with a dose of 80U three times/week. The disease improved after 16 months and then dose was decreased to 80U twice/week and continued for maintenance. |
| 5 | F | 35 | Idiopathic panuveitis | OS | 20 | No | Adalimumab | - | Obesity, HTN | RCI started with a dose of 80U three times/week. The disease improved after 2 months and then the dose was decreased to 80U twice/week. However, due to insurance coverage, RCI was stopped and IMT initiated. |
| 6 | M | 65 | Idiopathic panuveitis | OS | 32 | 15 | MMF switched to adalimumab | Insomnia, weight gain | - | RCI started with a dose of 80U three times/week. The condition improved after 2 months and then the dose was tapered down to 80U twice/week. Due to adequate control of inflammation RCI was tapered and stopped. |
| 7 | M | 64 | Retinal vasculitis | OD | 10 | 3 | Adalimumab | Elevated BG, HTN, LEE, Infection | DMTII | RCI started with a dose of 80U three times/week. Even though the disease was stable, due to side effects the RCI was tapered and stopped. |
| 8 | F | 27 | IBD associated retinal vasculitis | OD | 9 | 5 | - | - | - | Prior to initiating the RCI, patient received IMT, however it was stopped. RCI started with a dose of 80U twice/week and increased to 80U three times/week based on the patient’s tolerance to control the inflammation. After four months, dose was reduced to 80U per week and continued for maintenance. |
| 9 | M | 29 | Idiopathic retinal vasculitis | OD | 18 | 20 | - | - | - | RCI was started at a dose of 80U three times/week, however due to insurance coverage RCI was stopped. |
| 10 | F | 54 | Idiopathic scleritis | OS | 12 | 5 | MTX | - | - | RCI was started at a dose of 80U three times/week and decreased to 80 U twice/week. RCI was stopped due to improvement and control of inflammation. |
| 11 | M | 71 | Scleroderma associated scleritis | OD | 12 | 7.5 | - | Insomnia, Elevated BG, LEE | - | RCI was started at a dose of 40U three time/week, however due to side effects it was stopped after a year. Scleritis was stable at the time of discontinuation. Patient was then lost to follow up. |
| 12 | F | 70 | Idiopathic scleritis | OS | 35 | 9 | MTX | - | - | RCI was started at a dose of 80U twice/week, then decreased after improvement to 40U weekly and continued for maintenance. |
| 13 | F | 60 | RA associated scleritis | OS | 35 | 5 | Adalimumab | Insomnia | Anemia | RCI was started at a dose of 80U three times/week, then tapered to 80U twice/week and continued for maintenance. |
| 14 | M | 36 | Celiac associated scleritis | OS | 33 | 40 | MMF | - | - | RCI was started at a dose of 80U twice/week, then tapered to 40U twice/week with improvement after one month and eventually due to control of inflammation RCI was tapered and stopped. |
| 15 | M | 46 | Idiopathic scleritis | OS | 22 | 8 | MTX switched to MMF | - | - | RCI was started at a dose of 80U three times/week, then after 10 months tapered to 40U three times/week. Due to control of inflammation RCI was tapered and stopped. |
| 16 | F | 27 | SLE associated scleritis | OS | 39 | 5 | MMF | Weight gain, HTN | Neutropenia | RCI was started at a dose of 80U five times/week, then tapered to 80U twice/week after 12 months and 40U twice/week after another year. Same dose was continued for maintenance. |
| 17 | F | 60 | RA associated scleritis | OS | 24 | 2.5 | MTX | - | - | RCI was started at a dose of 40U three/week, then decreased to 40U twice/week due to improvement after 6 months. Same dose was continued for maintenance. |
mg = Milligram, IMT = Immunomodulatory therapy, SLE = Systemic lupus erythematosis, HTN = hypertension, RCI = Repository corticotropin injection, HLA = Human leukocyte antigen, M = Male, F = Female, OID = Ocular inflammatory diseases, OD = Right eye, OS = Left eye, MTX = Methotrexate, MM = Mycophenolate mofetil, LEE = lower extremity edema, DMTII = Diabetes mellitus type 2, RA = Rheumatoid arthritis