Fig. 3. Variation of percent GIA ranges and immune susceptibility profiles of P. falciparum clinical isolates to PfRH5-vaccine-induced mAbs at 150 µg/ml.
Dot plots of %GIA to anti-PfRH5 mAbs (Y-axis) of P. falciparum clinical isolates (X-axis). The %GIA susceptibility ranges in blue are defined as the mean 3D7%GIA (red dotted line) ± 3 SD 3D7%GIA (black dotted lines). Black dots represent isolates laying within the defined susceptibility ranges. Red dots represent isolates reflecting a reduced GIA susceptibility phenotype (bright red) or laying at the borderline (dim red) of the lower limit of the defined susceptibility threshold. Blue dots represent isolates showing an increased GIA susceptibility (bright blue) or laying at the borderline (dim blue) of the upper limit of the defined susceptibility threshold.