Figure 6.

Inhibition of RhoK partially attenuates TNF-α–mediated inhibitory effects on EC proliferation and cyclin A promoter activity. (A and B) Cotreatment of cells with Y27632 in the presence of TNF-α attenuates the inhibitory effect of TNF-α as measured by EC proliferation (A) and cyclin A promoter activity (B). (C) Overexpression of constitutively active (CA) RhoK mimics the effect of TNF-α on EC proliferation, while dominant-negative (DN) RhoA reverses it, as measured by ³H-thymidine uptake assay. *P < 0.01; **P < 0.001.