Figure 5.

Differentially expressed genes by their involvement in specific signaling pathways. Representative defects in T cell pathways and functions caused by CLL cell–T cell contact are shown in this diagram. Differentially expressed genes involved in cell differentiation, particularly JNK (pink) and p38 MAPK (yellow) pathways and cytoskeleton formation and vesicle transportation (blue), in CD4 T cells from CLL patients compared with healthy donors are represented by selected genes that were increased (rectangles) or decreased (ovals). Differentially expressed genes involved in cytoskeleton formation, vesicle trafficking (blue), and cytotoxicity (red) in CD8 T cells from CLL patients compared with healthy donors are represented by selected increased genes (rectangles) and decreased genes (ovals).