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. 2024 Oct 24;14:453. doi: 10.1038/s41398-024-03161-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Timeline of treatment with rh Bri2 BRICHOS R221E monomer or administration of vehicle (phosphate-buffered saline, PBS) in App^NL-G-F and age-matched WT mice. B Rh Bri2 BRICHOS R221E monomer analysis by reducing (lane 1) and non-reducing (lane 2) SDS-PAGE. M shows the migration of marker proteins with molecular masses in kDa given to the left. The Bri2 BRICHOS R221E structure at the top was predicted by Alphafold2 [93]. C Body weight of the vehicle (veh)- or rh Bri2 BRICHOS R221E-treated App^NL-G-F (App) and WT mice during the treatment period, presented as mean ± SEM. Two-way ANOVA with Tukey’s correction for multiple comparisons was used to calculate p-values for differences in body weight. ns no significance. D Areas of the hippocampus and cerebral cortex analysed by immunohistochemistry. Auditory auditory cortex, CA Cornu ammunis, DG dentate gyrus, Olfactory olfactory cortex, RSC retrosplenial cortex.