Fig. 3. Plaque load is reduced in App^NL-G-F mice after rh Bri2 BRICHOS R221E treatment.

Representative images of the hippocampus (A, B) and cerebral cortex (C–E) sections from vehicle (veh)- and rh Bri2 BRICHOS R221E-treated App^NL-G-F (App) mice stained with anti-Aβ antibody 82E1. Histograms show plaque load (%) in different hippocampal and cortical regions. The scale bar represents 400 μm and applies to all panels in (A–E). Data are presented as mean ± SEM (n = 6–7 mice/group). An unpaired parametric two-tailed t-test was used for statistical analysis. ^∗p < 0.05. Auditory auditory cortex, CA Cornu ammunis, DG dentate gyrus, Olfactory olfactory cortex, RSC retrosplenial cortex.