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. 2024 Oct 24;14:453. doi: 10.1038/s41398-024-03161-x

Fig. 8. Genes affected by rh Bri BRICHOS R221E treatment in relation to plaque-induced genes and genes in microglia subpopulations.

Fig. 8

Venn diagrams illustrating differentially expressed genes (DEGs) in the vehicle (veh)-treated WT and AppNL-G-F (App) mice (green circle), veh- and rh Bri2 BRICHOS R221E-treated AppNL-G-F mice (red circle), and A plaque-induced genes (PIGs, blue circle); B activated response microglia genes (ARMs, blue circle); and C disease-associated microglia genes (DAMs, blue circle). Histograms of normalized (NOR) counts for the four treatment groups of genes in the indicated intersections for panels (A, B) are shown to the right. For panel C, the genes in the indicated intersection are identified in Supplementary Excel file 2, together with genes in intersections from panels (A, B). See main text for details. n = 3 mice/group, one-way ANOVA test and Tukey’s test were used for statistical analysis. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, 0.05 < #p < 0.1.