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. 2024 Oct 25;4:215. doi: 10.1038/s43856-024-00648-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 1 — a Experimental design for HSCT strategy, Created with BioRender.com. Recipient mice at 4 weeks of age, N = 10 by sex and group were irradiated in a Cs¹³⁷ irradiator at 750 cGy. Mice received 10 million bone marrow cells isolated from Sumf1^(+/+) CD45.1⁺ (JaxBoy) or Sumf1^(S153P) for syngeneic control. b At one and 2 months post-transplant, the engraftment efficiency was tested by FACS on PBL’s from Sumf1^(S153P) and Sumf1^(+/+) recipients. The frequency of circulating leukocytes CD45.1⁺ and CD45.2⁺ is reported as percentage of total CD45⁺ cells. c After 10 months post-transplant, engraftment efficiency was analyzed by FACS in spleen and bone marrow. d Major leukocyte populations were analyzed in spleen. Data points represent individual mouse, and bar graphs display mean ± SEM. Multiple comparisons test using Kruskal-Wallis method. Exact P values are in Supplementary Data 1.