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. 2024 Oct 25;4:215. doi: 10.1038/s43856-024-00648-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 4 — Microglia assessed by Iba-1 immunohistochemistry on brain of Sumf1^(+/+) no-BMT, Sumf1^(S153P) no-BMT, recipient Sumf1^(+/+) + BM-Sumf1^(+/+), recipient Sumf1^(S153P) + BM-Sumf1^(S153P), and recipient Sumf1^(S153P) + BM-Sumf1^(+/+) at 10 months post-transplant. Representative images from hippocampus (a), motor cortex (b), visual cortex (c), and cerebellum (d). Microgliosis is represented as the percentage of stained area for Iba-1, and as percentage of Iba-1⁺ cells over total nucleated cells, in hippocampus (CA1) (e, i), motor cortex (f, j), visual cortex (g, k) and cerebellum (h, l) shown as bar graphs with mean ± SEM, dots represent individual mouse. Images (a–c) at x20 magnification, 50 μm scale bar. Images for cerebellum at x40, 25 μm scale bar. The black arrows point to vacuolated Iba-1⁺ cells. Multiple comparisons using Brown-Forsythe and Welch ANOVA tests. Exact P values are in Supplementary Data 1.