Figure 1. Case-control and prospective cohort studies generated from UK Biobank data. Start of observation for the prospective study 6 months after the assessment date. Person 1: registry-reported breast cancer 2 years after the day of first assessment, and no prior cancers; contributes to both studies. Person 2: registry-reported prostate cancer prior to the first day of assessment; contributes to case-control study only. Person 3: self-reported ovarian cancer prior to the first day of assessment, and no registry-reported cancers; excluded from both studies. Person 4: registry-reported lung cancer 3 years after the day of first assessment; contributes to both studies. Person 5: registry-reported colon cancer 4 months after the start of observation; contributes to case-control study only. Person 6: no self-reported nor registry-reported cancers; contributes to both studies. RR: registry-reported cancer. SR: self-reported cancer.