Figure 3. Relapse activity over time since first clinical episode with respect to threshold dosing (≥12.5 mg daily). (A) Kaplan-Meier survival time to first relapse curves with patients stratified by time spent above threshold dosing. Adjusted Cox proportional hazard ratios, with ‘never’ stratum as the reference group, are annotated. The median (IQR) cumulative oral corticosteroid dose (mg) for the <1.5 months, 1.5 to <3 months and ≥3 months groups are 1085 (631–1807), 2540 (1722–3538) and 4345 (3761–5965), respectively. (B) Annualised relapse rates were compared for each month after onset clinical episode, between patients above threshold dose and those below. Data for each group were aggregated from multiple patient-days in their respective months. The number of patients and patient-days contributing to each group are tabulated.