Table 2. Univariate and multivariable Cox proportional hazard models of time to first relapse.
| Covariate | n | Univariate | Multivariable | |||
| HR (95% CI) | P value | HR (95% CI) | P value | |||
| Onset age (years) | 109 | 1 (0.99 to 1.01) | 0.80 | 1 (0.98 to 1.01) | 0.48 | |
| Sex assigned at birth | Female | 62 | 1.00 (reference) | – | 1.00 (reference) | – |
| Male | 47 | 1.25 (0.79 to 1.97) | 0.34 | 1.45 (0.9 to 2.34) | 0.13 | |
| Initial phenotype | No ON | 51 | 1.00 (reference) | – | – | – |
| ON | 58 | 1.24 (0.78 to 1.96) | 0.36 | – | – | |
| No TM | 100 | 1.00 (reference) | – | – | – | |
| TM | 10 | 0.54 (0.2 to 1.48) | 0.23 | – | – | |
| No ADEM | 90 | 1.00 (reference) | – | – | – | |
| ADEM | 19 | 0.83 (0.45 to 1.54) | 0.56 | – | – | |
| Onset episode severity | EDSS<3 | 18 | 1.00 (reference) | – | 1.00 (reference) | – |
| EDSS≥3 | 71 | 0.71 (0.39 to 1.3) | 0.27 | 0.75 (0.38 to 1.46) | 0.40 | |
| Missing | 20 | 0.58 (0.27 to 1.23) | 0.15 | 0.49 (0.21 to 1.11) | 0.088 | |
| Onset episode severity (VFSS) | 54 | 1.06 (0.86 to 1.31) | 0.56 | – | – | |
| Time from initial symptoms to corticosteroids | <7 days | 41 | 1.00 (reference) | – | 1.00 (reference) | – |
| ≥7 days | 62 | 1.09 (0.62 to 1.93) | 0.76 | 1.04 (0.59 to 1.85) | 0.89 | |
| No treatment | 18 | 1.72 (0.86 to 3.4) | 0.12 | 1.71 (0.81 to 3.62) | 0.16 | |
| Cumulative IV corticosteroid dose (g) | 109 | 0.96 (0.9 to 1.02) | 0.18 | – | – | |
| Oral corticosteroid dose (mg/day) | 109 | 0.96 (0.93 to 0.99) | 0.0078 | 0.96 (0.93 to 0.99) | 0.014 | |
| IVIg or PLEX given as acute immunotherapy | Not given | 100 | 1.00 (reference) | – | – | – |
| Given | 9 | 0.8 (0.32 to 1.99) | 0.63 | – | – | |
ADEM, acute disseminated encephalomyelitis; EDSS, Expanded Disability Status Score; IVIg, intravenous immunoglobulin; ON, optic neuritis; PLEX, therapeutic plasma exchange; TM, transverse myelitis; VFSS, Visual Functional System Score