Table 2. QUADAS-2 quality assessment summary—review authors’ judgements.

Study	Risk of bias				Applicability concerns
	Patient selection	Index test	Reference standard	Flow and timing	Patient selection	Index test	Reference standard
Chun and Siu14	High	Unclear	Unclear	Unclear	Low	Low	Low
Giachino et al15	Low	High	Unclear	Unclear	Low	Low	Low
Lian et al16	Low	High	Unclear	Unclear	Low	Low	Low
Meng et al17	High	High	Unclear	Unclear	High	High	Low
Morello et al18	High	Low	Low	Low	Unclear	Low	Low
Morello et al19	Low	High	Low	Low	Low	Low	Low
Morello et al20	High	High	Low	High	Low	Low	Low
Morello et al21	Unclear	High	Low	High	Low	Low	Low
Peng et al22	High	High	Unclear	Low	High	Low	Low
Suzuki et al23	High	High	Unclear	Unclear	Unclear	Low	Low
von Kodolitsch et al24	Unclear	Unclear	Unclear	High	Unclear	Low	Low
Wang et al25	High	High	Unclear	Low	High	Low	Low
Zhang et al26	Low	High	Unclear	High	Low	Low	Low

QUADAS-2Quality Assessment of Diagnostic Accuracy Studies 2