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Secondary minor biotransformation reactions after linker-payload deconjugation. (A) Formation of the HC-LC inter chain disulfide bond increases with time; the inset figure showed the extracted ion chromatograph for ADC 3 at various time points. PD = post dose. (B) Cysteinylation changes over time. (C) Quantification of the thio-succinimide hydrolysis of albumin-linker payload. Representative MS1 spectra can be found in Figures S5 and S7.
