Table 1. List of Biotransformation Species Identified (LC: Light Chain, HC: Heavy Chain, PL: Payload, Cys: Cysteine, H2O: Thio-Succinimide Ring Hydrolysis).
| index | monitoring species | index | monitoring species | index | monitoring species |
|---|---|---|---|---|---|
| 1 | LC + 1PL | 15 | HC + 2PL + G0F + 2H2O | 29 | HC + 3PL + G0F + 2H2O |
| 2 | LC + 1PL + H2O | 16 | HC + 2PL + G1F + 2H2O | 30 | HC + 3PL + G1F + 2H2O |
| 3 | LC | 17 | HC + 2PL + G0F + GSH | 31 | HC + 3PL + G0F + 3H2O |
| 4 | LC + Cys | 18 | HC + 2PL + G1F + GSH | 32 | HC + 3PL + G1F + 3H2O |
| 5 | HC + G0F | 19 | HC + 2PL + G0F + Cys | 33 | LC + HC + 2PL + G0F |
| 6 | HC + G1F | 20 | HC + 2PL + G1F + Cys | 34 | LC + HC + 2PL + G1F |
| 7 | HC + 1PL + G0F | 21 | HC + 2PL + G0F + H2O + Cys | 35 | LC + HC + 2PL + G0F + H2O |
| 8 | HC + 1PL + G1F | 22 | HC + 2PL + G1F + H2O + Cys | 36 | LC + HC + 2PL + G1F + H2O |
| 9 | HC + 1PL + G0F + H2O | 23 | HC + 2PL + G0F + 2H2Os + Cys | 37 | LC + HC + 2PL + G0F + 2H2O |
| 10 | HC + 1PL + G1F + H2O | 24 | HC + 2PL + G1F + 2H2O + Cys | 38 | LC + HC + 2PL + G1F + 2H2O |
| 11 | HC + 2PL + G0F | 25 | HC + 3PL + G0F | 39 | albumin |
| 12 | HC + 2PL + G1F | 26 | HC + 3PL + G1F | 40 | albumin + Cys |
| 13 | HC + 2PL + G0F + H2O | 27 | HC + 3PL + G0F + H2O | 41 | albumin +1PL |
| 14 | HC + 2PL + G1F + H2O | 28 | HC + 3PL + G1F + H2O | 42 | albumin +1PL + H2O |