Figure 5.

Cell association summary of PEG, PEG-MS, and Doxil nanoparticle systems (with and without BsAb functionalization) in the whole blood of 15 CLL patients. (a–c) Violin plots summarizing the association of nonfunctionalized and BsAb-functionalized PEG, PEG-MS, and Doxil nanoparticles with CLL cells, T cells, monocytes, granulocytes, and NK cells in CLL patient blood after 1 h incubation at 37 °C. (d) Cross-comparison of the three particle systems of their association with CLL cells, T cells, monocytes, and granulocytes in CLL patient blood. Each data point represents the mean of three independent experiments (using the same batch of fresh blood from each donor). The median cell association across 15 CLL patients is shown as a solid line in the violin plots.