Figure 2.

Increase in cytosolic Ca²⁺ induced by Gq-coupled agonists in single cells of the olfactory epithelium of HS and SZ patients. Cells were cultured for three days to assess changes in intracellular Ca²⁺ concentration ([Ca²⁺]_i) induced by 300 μM ATP (A), 300 μM UTP (B), 10 μM serotonin (C), and 10 μM epinephrine (D) by microfluorometry using Fura 2-AM. The graphs represent the data obtained from six subjects per group. Each data point represents the average of three technical replicates for each subject. Data were expressed as mean ± SEM and compared using the Student’s t-test with Welch’s correction, * p < 0.05 ** p < 0.01 **** p < 0.001. HS = healthy subject (blue), SZ = schizophrenic patient (red).