Figure 3.

Phage therapy strategies to counter bacterial resistance include the combination of multiple highly efficient phages into phage cocktails; phage genetic engineering to remove genes involved in lysogeny, antibiotic resistance or virulence factors; phage evolution, which allows the obtention of phages with higher killing efficacies and expanded host ranges; and, finally, the combination of phages or phage-derived products (e.g., lysins) with antibiotics to increase bactericidal activity. Image created with BioRender.com.