Figure 8.

STRING network of correlated and significant genes in GBM. To identify therapeutic targets for GBM, we employed a comprehensive analytical approach that integrates DEG analysis, correlation analysis, and tissue expression data from the Human Protein Atlas. We began by selecting genes with correlation coefficients (absolute value of R ≥ 0.4) from Figure 7. Additionally, we included upregulated DEGs from brain-expressed genes depicted in Figure 7 and incorporated relevant genes from Figure 6. These genes were then analysed using the STRING database, with unconnected genes hidden and default parameters applied. This extensive analysis highlighted critical marker genes that play significant roles in the dynamics of GBM tumours. The network genes are stored in Supplementary Materials.