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. 2023 Dec 31;2(2):98–116. doi: 10.1021/cbmi.3c00117

Figure 10.

Figure 10

(a) Synthesis and chemical structure of probe [18F]SF-DEVD and proposed possible self-assembly mechanism of the probe. (b) Proposed action mechanism of [18F]SF-DEVD for detecting caspase-3 activity in tumor cells. (c) Transversal and coronal PET images of HeLa-tumor-bearing mice from 10 to 60 min. (d) Time course of tumor and muscle uptake of [18F]SF-DEVD in the mice with or without DOX treatment. (e) Synthesis and chemical structure of tracer [18F]SF-Glu. (f) Cellular uptake assay of probe [18F]SF-Glu in U87 and NCI-H1299 cells. (g) Transversal and coronal PET images of U87- and NCI-H1299-tumor-bearing mice from 10 to 60 min. (h) Time course of tumor and muscle uptake of [18F]SF-Glu in U87- and NCI-H1299-tumor-bearing mice (n = 3). ***P < 0.001. Reproduced with permission from ref (92). Copyright 2022 American Chemical Society.