Figure 7.

(a) Chemical structures for the probe DEVDC_S-Gd-CBT, which responds to caspase-3 to form Gd-NPs under a reduction condition, and schematic illustration of DEVDC_S-Gd-CBT for enhanced T₁-weighted MRI of apoptosis in zebrafish. (b) T₁-weighted MR images of zebrafish in the group “Healthy + PBS,” group “Tail Amputation + PBS,” group “Healthy + DEVDC_S-Gd-CBT,” and group “Tail Amputation + DEVDC_S-Gd-CBT.” Lesion/body grayscale value ratios of MR images (right). Each error bar represents the standard deviation of three independent experiments (mean ± SD, ***P < 0.001). Reproduced with permission from ref (82). Copyright 2023 American Chemical Society.