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. 2023 Dec 31;2(2):98–116. doi: 10.1021/cbmi.3c00117

Figure 8.

Figure 8

(a) The chemical structures of probe C-SNAM (2) and its control probe 2-ctrl and the proposed chemical conversions following disulfide reduction and caspase-3/7-triggered DEVD peptide cleavage. (b) Representative T1-weighted MR images (1 T) of HeLa tumors prior to (baseline) or following treatment with DOX (treated). Images were obtained before (precontrast) and 40 and 120 min after iv injection of 0.1 mmol kg–1 of 2 or 2-ctrl. The average longitudinal % signal enhancement (% SE) is represented in baseline (●) and treated (○) tumors after iv injection of 2 (n = 8) or 2-ctrl (n = 4) at 0.1 mmol kg–1 dose. The tumor signal intensity (SI) was normalized to the reference standard in a mini-NMR tube (1 mM of Dotarem in PBS), and % SE was calculated at each time point as the % difference between the tumor SI at that time point and the tumor SI in the precontrast (t = 0) data set. *P < 0.05. Error bars are standard deviations. Reproduced with permission from ref (83). Copyright 2014 Royal Society of Chemistry.