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. 2023 Dec 31;2(2):98–116. doi: 10.1021/cbmi.3c00117

Table 1. Summary of Bioimaging Probes Based on Enzyme-Instructed CBT-Cys-like Click Reactions.

probe enzyme cyclization type imaging modalities reactions type reference
Cys(StBu)-IEFD-K(Cy5.5)-CBT granzyme B intermolecular cyclization FL CBT-Cys (41)
QMT-CBT caspase 1 intermolecular cyclization FL CBT-Cys (45)
Ac-RVRR(StBu)-K(TPE)-CBT furin intermolecular cyclization FL CBT-Cys (48)
Cbz-GPC(StBu)K(Cou)-CBT FAP-α intermolecular cyclization FL CBT-Cys (55)
C-SNAF caspase-3/7 intramolecular cyclization FL CHQ-Cys (57)
TCO-C-SNAT4 caspase-3/7 intramolecular cyclization FL PMN-Cys (59)
NI–C–CBT nitroreductase intermolecular cyclization PA CBT-Cys (67)
Val-Cit-Cys(SEt)-Lys(Cypate)-CBT cathepsin B intermolecular cyclization PA CBT-Cys (70)
1-RGD caspase-3 intramolecular cyclization PA CHQ-Cys (71)
DEVDCS-Gd-CBT caspase-3 intermolecular cyclization MRI CBT-Cys (82)
C-SNAM caspase-3/7 intramolecular cyclization MRI CHQ-Cys (83)
Ac-DEVD-C(StBu)-K-CBT-Fe3O4 NPs caspase-3/7 intermolecular cyclization MRI CBT-Cys (85)
Ac-RVRR-C(StBu)-K(SPIO)-CBT furin intermolecular cyclization MRI CBT-Cys (86)
[18F]SF-DEVD caspase-3 intramolecular cyclization PET CBT-Cys (92)
[18F]SF-Glu GGT intramolecular cyclization PET CBT-Cys (92)
[18F]C-SNAT caspase-3 intramolecular cyclization PET CHQ-Cys (93)
[18F]C-SNAT4 caspase-3 intramolecular cyclization PET PMN-Cys (94)
Ac-RVRR-C(StBu)-K(DOTA-68Ga)-CBT furin intermolecular cyclization PET CBT-Cys (96)
Gd-IR780 caspase-3 intramolecular cyclization PA/MRI CHQ-Cys (99)
[18F]-IR780–1 caspase-3 intramolecular cyclization PA/PET CHQ-Cys (100)
AuNNP@DEVD-IR1048 caspase-3 intermolecular cyclization PA/FL CBT-Cys (101)