Systematic review flowchart of clinical trials using Azithromycin during the coronavirus disease (COVID)-19 pandemic. We included in our systematic review a total of three studies (Cavalcanti et al., 2020; Furtado et al., 2020; RECOVERY Collaborative Group, 2021) [35,36,37]. The data search was performed on PubMed-Medline, Cochrane, and SciELO from the COVID-19 pandemic onset to December 2023. The following search was performed: (((Azithromycin) OR (Antibiotics) OR (Macrolides)) AND ((COVID-19) OR (COVID-19 treatments) OR (COVID-19 pandemic) OR (SARS-CoV-2) OR (SARS-CoV-2 infection))) AND (Therapy/Narrow[filter]) AND (randomized controlled trial[pt] OR controlled clinical trial[pt] OR clinical trials as topic[mesh:noexp] OR trial[ti] OR random*[tiab] OR placebo*[tiab]). RCT, randomized controlled trial. *, The 257 studies that were excluded from different criteria were presented separately due to the low number of studies per criteria.