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. 2024 Oct 17;13(10):1250. doi: 10.3390/antiox13101250

Figure 2.

Figure 2

Effects of aged-to-young FMT on endothelial function. Representative traces for endothelium-dependent relaxations (EDRs) in (A) aortas and (B) mesenteric arteries of Aged, young-transplanted (Young (Control)) and aged-transplanted mice (Young (FMT)). Summary statistics of wire myography on EDRs in (C) aortas and (D) mesenteric arteries from different mouse groups. (E) Dihydroethidium (DHE) staining on en face endothelium of different mouse groups, and (F) corresponding quantification of DHE fluorescence. (G) Lucigenin-enhanced chemiluminescence on aortic ROS levels of different mouse groups. (H) Nitrite levels in aortas of different mouse groups. N = 8 per group. (I) Representative Western blots, and (J,K) quantification of Western blotting on expression of AMPK, p-AMPK at Thr172, eNOS and p-eNOS at Ser1177 in aortas of different mouse groups. N = 6 per group. Data are mean ± SD. * p < 0.05; Brown-Forsythe and Welch ANOVA and Dunnett T3 test.