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. 2024 Sep 11;5(10):1494–1514. doi: 10.1038/s43018-024-00821-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — (a) Table summarizing average EC₅₀ (pM) killing values in the absence or presence of soluble factors (sBCMA, APRIL and sCD38) for ISB 2001, teclistamab, EM801 and alnuctamab in KMS-12-BM cell line. (b) EC₅₀ killing potency of ISB 2001, teclistamab, EM801 and alnuctamab against the KMS-12-BM cell line in the presence of sBCMA, APRIL or sCD38 alone. PBMC were used as effector cells at a 5:1 ratio.Log₁₀(EC₅₀) (n = 6 PBMC donors from 2 experiments) were compared using repeated measure ANOVA model and Tukey HSD comparison and statistical differences are shown only to compare ISB 2001 to TCEs for each soluble factors when statistically significant (P < 0.05).

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