Table 1.

Main effects of quercetin on thyroid cancer cell lines.

Type of Thyroid Cancer	Cell Lines	Effects	References
Differentiated papillary	TPC-1	Growth inhibition	[46]
	K1	Growth inhibition Decrease of hnRNPA1 protein Increase the effects of bromodomain and extraterminal domain inhibitors on cell apoptosis and sphere-forming ability Synergic effect with sorafenib on growth and EMT inhibition	[67,69]
Differentiated follicular	FTC-133	Growth inhibition Decrease of CD97 expression Induction of NIS expression	[46]
Poorly differentiated papillary	NPA	Growth inhibition Decrease of CD97 expression Induction of NIS expression	[46]
	B-CPAP	Growth inhibition Decrease of cytokines production Apoptosis Decrease of Hsp90 expression Decrease of cell adhesion and migration Decrease of N-cadherin expression Decrease of MMP-9 expression Increase of E-cadherin expression Increase of NIS expression and radio-iodine uptake Synergic effect with sorafenib on growth and EMT inhibition	[64,65,66,69]
Anaplastic	ARO	Growth inhibition Decrease of CD97 expression	[46]
	FRO	Growth inhibition Decrease of CD97 expression Induction of NIS expression	[46]
	8505c	Growth inhibition Decrease of hnRNPA1 protein levels Increase the effects of bromodomain and extraterminal domain inhibitors on cell apoptosis and sphere-forming ability	[67]
Metastatic papillary	MDA-T85	Growth inhibition Decrease of hnRNPA1 protein levels Increase the effects of bromodomain and extraterminal domain inhibitors on cell apoptosis and sphere-forming ability	[67]
Medullary	TT	Growth inhibition Decrease of cytokines production	[64]