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. 2024 Oct 13;14(10):1294. doi: 10.3390/biom14101294

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The average mean diffusivity (MD) within each region of interest (ROI) was decreased in 5xFAD brains of both age groups. The MD was found consistently decreased in all ROIs of 5xFAD brains compared to WT brains. However, this difference between genotypes was not statistically significant. Additionally, while a small age-related increase in MD was observed in all ROIs for both genotypes, this difference was mainly evident in 5xFAD brains. Group means with 95% confidence intervals are superimposed on the individual observations. 2M = 2-month-old, 6M = 6-month-old. Sub = subiculum, CA = cornu ammonis of the hippocampal formation, hip = hippocampus, CC = corpus callosum, WM = white matter, LC = lower cortex, UC = upper cortex, and neo = neocortex.